Arsenic Trioxide (TRISENOX) 1mg/ml concentrate for ...
Nov 18, 2019· The active substance is arsenic trioxide. Each ml of concentrate contains 1 mg of arsenic trioxide. Each ampoule of 10 ml contains 10 mg of arsenic trioxide. The other ingredients are sodium hydroxide, hydrochloric acid and water for injections. See section 2 …
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The new england journal medicine
n engl j med 369;2 nejm july 11, 2013 111 The new england journal of medicine established in 1812 july 11, 2013 vol. 369 no. 2 Retinoic Acid and Arsenic Trioxide for Acute Promyelocytic Leukemia
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Arsenic Trioxide Controls the Fate of the PML-RARα ...
Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As2O3) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARα (a fusion protein containing sequences from the ...
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Arsenic Trioxide Injection - FDA prescribing information ...
May 09, 2020· Drugs provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex (updated 4 May 2020), Cerner Multum™ (updated 2 June 2020), …
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The new england journal medicine
Retinoic Acid and Arsenic Trioxide for APL n engl j med 369;2 nejm july 11, 2013 113 or the writing of the manuscript. Arsenic trioxide was donated for this investigation by Cephalon
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Arsenic Trioxide (TRISENOX) 1mg/ml concentrate for ...
Nov 18, 2019· Those serious adverse reactions attributed to arsenic trioxide included APL differentiation syndrome (3), leucocytosis (3), prolonged QT interval (4, 1 with torsade de pointes), atrial fibrillation/atrial flutter (1), hyperglycaemia (2) and a variety of serious adverse reactions related to haemorrhage, infections, pain, diarrhoea, nausea.
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Trioxide - definition of trioxide by The Free Dictionary
tri·ox·ide (trī-ŏk′sīd′) also tri·ox·id (-ŏk′sĭd) n. An oxide containing three oxygen atoms per molecule. trioxide (traɪˈɒksaɪd) n (Elements & Compounds) any oxide that contains three oxygen atoms per molecule: sulphur trioxide, SO3. tri•ox•ide (traɪˈɒk saɪd, -sɪd) n. an oxide containing three oxygen atoms, as As2O3. [1865 ...
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Trisenox® (arsenic trioxide) injection
With TRISENOX ® (arsenic trioxide) injection + tretinoin 1. Indication. TRISENOX is indicated in combination with tretinoin for treatment of adults with newly-diagnosed low-risk acute promyelocytic leukemia (APL) whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression.
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Glutathione depletion overcomes resistance to arsenic ...
May 15, 2003· Arsenic trioxide (As 2 O 3) is an effective treatment for acute promyelocytic leukemia (APL), but is less effective against other leukemias.Although the response of APL cells to As 2 …
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[Product Monograph Template - Standard]
o Arsenic trioxide can cause QT prolongation and complete atrioventricular block. QT prolongation can lead to torsade de pointes, a polymorphic ventricular tachyarrhythmia, which can be fatal (see WARNINGS AND PRECAUTIONS, Cardiovascular). o Patients with syncope, rapid or irregular heartbeat should be hospitalized for monitoring.
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Effective Treatment of Acute Promyelocytic Leukemia With ...
Feb 01, 2009· Arsenic trioxide (ATO) is effective for treatment of patients with APL who have experienced relapse after prior therapy with ATRA-containing regimens. 15,16 A recent large randomized study showed that the addition of two courses of ATO consolidation after CR significantly improved DFS and OS. 3 ATO is also active as a single agent in front-line ...
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DailyMed - ARSENIC TRIOXIDE injection
Mar 03, 2020· Arsenic Trioxide Injection is a sterile injectable solution of arsenic trioxide. The molecular formula of the drug substance in the solid state is As 2 O 3, with a molecular weight of 197.8 and has the following structural formula: Arsenic Trioxide is available in 10 mL, single-use vials containing 10 mg of arsenic trioxide.
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Arsenic trioxide - Wikipedia
Arsenic trioxide, sold under the brand name Trisenox among others, is an inorganic compound and medication. As an industrial chemical, major uses include in the manufacture of wood preservatives, pesticides, and glass. As a medication it is used to treat a type of cancer known as acute promyelocytic leukemia. For this use it is given by injection into a vein.
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Arsenic(III) oxide | CAS No. | Sigma-Aldrich ...
Arsenic(III) oxide 99.995% trace metals basis Synonym: ATO, Arsenic trioxide, Arsenous acid, Diarsenic trioxide; CAS Number . Empirical Formula (Hill Notation) As 2 O 3. Molecular Weight 197.84 . EC Number 215-481-4. MDL number MFCD00003433. eCl@ss 38080102 . PubChem Substance ID 24852110. NACRES NA.22
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Arsenic Trioxide Side Effects & Interactions | RxSaver by ...
Therefore, before using arsenic trioxide, report all medications you are currently using to your doctor or pharmacist. Some products that may interact with this drug are: aspirin and other NSAIDs (e.g., ibuprofen), drugs that lower blood minerals (e.g., amphotericin B), drugs that may harm the immune system (e.g., chemotherapy).
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Régulation de la SUMOylation, de la phosphorylation et de ...
Faculté de médecine – Thèses et mémoires; View Item; JavaScript is disabled for your browser. Some features of this site may not work without it. Search Papyrus. Search this Collection. My Account. To submit an item or subscribe to email alerts. Login. New user? Browse.
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Pharmacokinetics of arsenic trioxide in patients with ...
Recent studies indicate arsenic dioxide (As 2 0 3) as a potent agent in the treatment of acute promyelocytic leukemia (APL).APL is characterized by the reciprocal chromosomal translocations of the gene encoding a retinoic acid receptor (RAR-α) on chromosome 17, and a transcription factor, PML, on chromosome 15.
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PNAS Plus: Arsenic trioxide targets MTHFD1 and SUMO ...
Mar 21, 2017· Arsenic exposure increases risk for cancers and is teratogenic in animal models. Here we demonstrate that small ubiquitin-like modifier (SUMO)- and folate-dependent nuclear de novo thymidylate (dTMP) biosynthesis is a sensitive target of arsenic trioxide (As 2 O 3), leading to uracil misincorporation into DNA and genome instability.. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) and ...
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Side effect information for Arsenic trioxide
License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions .. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only.
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Diarsenic trioxide - Substance Information - ECHA
Hazard classification & labelling Hazard classification and labelling. The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to ...
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Arsenic Trioxide Phebra 1 mg/ml concentrate for solution ...
Arsenic Trioxide Phebra must be administered intravenously at a dose of 0.15 mg/kg/day, given daily until complete remission is achieved. If complete remission has not occurred by day 60, dosing must be discontinued. Consolidation schedule. Arsenic Trioxide Phebra must be administered intravenously at a dose of 0.15 mg/kg/day, 5 days per week.
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Arsenic: Uses, Side Effects, Interactions, Dosage, and Warning
Overview Information Arsenic is a trace element. It is found in several foods including seafood, poultry, grains (especially rice), bread, cereal products, mushrooms, and dairy products.
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Acute and chronic arsenic toxicity
Acute arsenic poisoning is associated initially with nausea, vomiting, abdominal pain, and severe diarrhoea. Encephalopathy and peripheral neuropathy are reported. Chronic arsenic toxicity results in multisystem disease. Arsenic is a well documented human carcinogen affecting numerous organs.
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Reagent Grade, Analytical Grade Powder Arsenic Trioxide ...
SLC Chemicals - Offering Reagent Grade, Analytical Grade Powder Arsenic Trioxide , 500gram at Rs 575/packet in Delhi, Delhi. Read about company. Get contact details and address | ID:
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The Arsenic Rule
The Arsenic Rule: Waste Disposal Options. Waste Streams, Impacts on disposal alternatives, anion exchange. Keywords: arsenic in drinking water, waste disposal, arsenic rule ...
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DailyMed - ARSENIC TRIOXIDE injection, solution
Nov 16, 2018· Arsenic trioxide injection is formulated as a sterile, nonpyrogenic, clear solution of arsenic trioxide in water for injection using sodium hydroxide and dilute hydrochloric acid to adjust to pH 8. Arsenic trioxide injection is preservative-free. Arsenic trioxide, the active ingredient, is present at a concentration of 1 mg/mL.
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Arsenic trioxide Uses, Side Effects & Warnings - Drugs
May 05, 2020· Arsenic trioxide is used to treat a cancer of the blood and bone marrow called acute promyelocytic (pro-MYE-loe-SIT-ik) leukemia, or APL. Arsenic trioxide is sometimes given in combination with another medicine called tretinoin.. Arsenic trioxide may also be used for other purposes not listed in this medication guide.
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Arsenic trioxide Side Effects: Common, Severe, Long Term ...
Mar 28, 2019· In Summary. Commonly reported side effects of arsenic trioxide include: pleural effusion, dyspnea, fever, leukocytosis, palpitations, prolonged qt interval on ecg, tachycardia, and weight gain.Other side effects include: cardiac arrhythmia. See below for a comprehensive list of adverse effects.
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HIGHLIGHTS OF PRESCRIBING INFORMATION TRISENOX …
Cardiac Conduction Abnormalities: Arsenic trioxide can cause QTc interval prolongation, complete atrioventricular block, and a torsade de pointes-type ventricular arrhythmia, which can be fatal. Before initiating therapy, assess the QTc interval, correct pre-existing …
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Long-term Safety Study of Arsenic Trioxide in Newly ...
Nov 23, 2018· Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed, Low-to-intermediate Risk Acute Promyelocytic Leukemia (APL0618) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
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Trioxid de arsen - Wikipedia
Denumiri alternative. Arsenic este o denumire frecvent folosită pentru trioxidul de arsen sau anhidrida arsenioasă.Este cunoscut și sub denumirile populare alternative de șar, săricica, șoricioaică, șoriceasă. (În prezent termenul este rar folosit în limba română pentru a denumi elementul chimic arsen.). Istoric. Arsenicul este cunoscut din antichitate. În Roma antică era ...
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Mechanisms of Action of Arsenic Trioxide | Cancer Research
Arsenic trioxide has shown substantial efficacy in treating both newly diagnosed and relapsedpatients with acute promyelocytic leukemia (APL). As a single agent, it induces complete remissions, causing few adverse effects and only minimal myelosuppression. These successes have prompted investigations to elucidate the mechanisms of action underlying these clinical responses.
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Arsenox, 1mg/ ml Arsenic Trioxide, India
Arsenox and 1mg/ ml Arsenic Trioxide is Anti-cancer Drugs. This is a chemotherapy drug and can treat leukemia. Manufacturer by is Intas Pharmaceuticals Ltd.
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Activation of the Nrf2 Signaling Pathway Involving KLF9 ...
Arsenic trioxide (As2O3) is both the most prevalent, naturally occurring inorganic arsenical threatening human health and an efficient therapeutic for acute promyelocytic leukemia. Regretfully, As2O3-treated cancer patients often suffer from hepatotoxicity. While effective antioxidant and anticarcinogenic actions of allicin have previously been demonstrated, studies indicating how allicin ...
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Chemistry of Arsenic - Arsenic - NCBI Bookshelf
ARSENOUS AND ARSENIC ACIDS. Presumably, when arsenic trioxide is dissolved in water, the solution contains o-arsenous acid, H 3 AsO 3.When As 4 O 6 was dissolved in an acidic aqueous solution, only the undissociated species, As(OH) 3, was detected. 745 Raman spectral and nuclear-magnetic-resonance studies 481 indicate that, unlike the phosphorous acid molecule, which has both …
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